Research
Neuronal circuits underlie all human behaviors, thoughts, emotions and memories. Defective communication within these neural circuits lead to neurodevelopmental, psychiatric, and neurodegenerative disorders. Our laboratory studies how brain circuit function, and ultimately behavior, is governed by molecular networks of proteins that are perturbed by genetic mutations that drive these disorders. Our current projects involve mouse models of disorders, studies of synapse function, and the utilization of cutting-edge proteomic and CRISPR approaches we have developed to unravel disease etiology.
Video abstracts of our recent publications in Nature and Neuron.