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307 Research Dr
Durham, NC, 27705
United States

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Synaptic Signaling Underlying Complex Brain Disorders

                      Recent Lab News: 
                       09/09/16- Our discovery of the elusive inhibitory postsynaptic complex using In Vivo BioID is published in Science.
                       08/10/16- Dr. Il Hwan Kim receives a NARSAD Young Investigator Award!
                       07/11/16- Rohit Ramnath becomes a newly minted Ph.D.  
                       05/15/16- Congrats to Shataakshi Dube on her Helmsley Scholarship.
                       04/05/16- Two new papers- one in Cell and one in Nature Neuroscience.
                       09/29/15- Congrats to Erin Spence on her NIH F31 Fellowship!!
                       

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Neural development of excitatory and inhibitory synapses and their ability to tune their strengths of connections in response to experience are essential for our ability to think, remember, express emotion, etc.  Abnormalities of these synaptic connections contribute strongly to Intellectual Disability, Autism, Alzheimer's disease, and Schizophrenia.  We are discovering the inner components of these synapses and the cellular mechanisms underlying these disorders.  Postdoctoral applicants interested in studying inhibitory or excitatory synapses with experience in behavior, optogenetics, neural circuit tracing, or electrophysiology and an excellent publication track record are encouraged to apply.

 

Below is an image of abnormal hippocampal network activity related to our Science paper.  In this paper (lead author, Akiyoshi Uezu) we describe an in vivo chemico-genetic proteomic approach to discover the elusive postsynaptic complex regulating GABAergic synapses.  For more on this approach see our In Vivo BioID page.