Synaptic Cell Biology Underlying Complex Brain Disorders
Recent Lab News:
01/23/19- New iBioID paper on the discovery of a novel protein important for newly forming excitatory synapses!
09/07/18- Congrats to Tetsuya Takano: The Award for Young Investigator of Japanese Society for Neurochemistry!
05/26/18- Announcing 3 new Soderling Lab PhD candidates! Eda Erata, Jamie Courtland, and Tyler Bradshaw successfully
passed their qualifying exams with flying colors!
05/25/18- Lab is very proud of Erin Spence for successfully defending her Ph.D. in Cell Biology!
05/20/18- Congrats to Erin Hisey for the Ruth K. Broad Fellowship!
04/06/18- First Patent Filed from the Lab. Keep an eye out for exciting future publications :)
12/15/17- Congrats to Tetsuya Takano being awarded the prestigious Uehara Memorial Foundation Fellowship!
03/17/17- Congrats to Shataakshi Dube on being awarded a National Science Foundation Graduate Research Fellowship!
1/24/17- Spectrum news article on the implications for our findings for autism.
Neural development of excitatory and inhibitory synapses and their ability to tune their strengths of connections in response to experience are essential for our ability to think, remember, express emotion, etc. Abnormalities of these synaptic connections contribute strongly to Intellectual Disability, Autism, Alzheimer's disease, and Schizophrenia. We are discovering the inner components of these synapses and the cellular mechanisms underlying these disorders. Postdoctoral applicants interested in studying inhibitory or excitatory synapses with experience in behavior, optogenetics, neural circuit tracing, or electrophysiology and an excellent publication track record are encouraged to apply.
Below is an image of abnormal hippocampal network activity related to our Science paper. In this paper (lead author, Akiyoshi Uezu) we describe an in vivo chemico-genetic proteomic approach to discover the elusive postsynaptic complex regulating GABAergic synapses. For more on this approach see our In Vivo BioID page.