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307 Research Dr
Durham, NC, 27705
United States

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Synaptic Cell Biology Underlying Complex Brain Disorders

                      Recent Lab News: 
                       05/26/18- Announcing 3 new Soderling Lab PhD candidates! Eda Erata, Jamie Courtland, and Tyler Bradshaw successfully
                                          passed their qualifying exams with flying colors!           
                       05/25/18- Lab is very proud of Erin Spence for successfully defending her Ph.D. in Cell Biology! 
                       05/20/18- Congrats to Erin Hisey for the Ruth K. Broad Fellowship! 
                       04/06/18- First Patent Filed from the Lab. Keep an eye out for exciting future publications :)  
                        12/15/17- Congrats to Tetsuya Takano being awarded the prestigious Uehara Memorial Foundation Fellowship!                      
                       03/17/17- Congrats to Shataakshi Dube on being awarded a National Science Foundation Graduate Research Fellowship!
                        1/24/17- Spectrum news article on the implications for our findings for autism. 
                       12/18/16- Our work is highlighted on the NPR show SciWorks Radio.
                       09/09/16- Our discovery of the elusive inhibitory postsynaptic complex using In Vivo BioID is published in Science.
                       08/10/16- Dr. Il Hwan Kim receives a NARSAD Young Investigator Award. 
                       05/15/16- Congrats to Shataakshi Dube on her Helmsley Scholarship.
                       04/05/16- Two new papers- one in Cell and one in Nature Neuroscience.

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Neural development of excitatory and inhibitory synapses and their ability to tune their strengths of connections in response to experience are essential for our ability to think, remember, express emotion, etc.  Abnormalities of these synaptic connections contribute strongly to Intellectual Disability, Autism, Alzheimer's disease, and Schizophrenia.  We are discovering the inner components of these synapses and the cellular mechanisms underlying these disorders.  Postdoctoral applicants interested in studying inhibitory or excitatory synapses with experience in behavior, optogenetics, neural circuit tracing, or electrophysiology and an excellent publication track record are encouraged to apply.


Below is an image of abnormal hippocampal network activity related to our Science paper.  In this paper (lead author, Akiyoshi Uezu) we describe an in vivo chemico-genetic proteomic approach to discover the elusive postsynaptic complex regulating GABAergic synapses.  For more on this approach see our In Vivo BioID page.