Recent Lab News:

04/28/25- Check our our new work using Protein Language Models and CRISPR-based proteomics to discover in vivo
mechanisms of kinase signaling! In collaboration with the Singh Lab we develop a new AI model, KolossuS, and
pair it with our new HiUGE-BioID. See the preprint for details and insights into the regulation of sleep!
08/16/24- Honey, we shrunk the proteins! In collaboration with the Singh Lab we show their new AI model, RayGun, can
shrink proteins while retaining function. Follow the preprint for more exciting updates!
08/09/24- BioID proteomics goes native using CRISPR genome engineering to create TurboID fusions of endogenous
proteins. Yudong Gao shows how this can reveal new mechanisms of autism.
08/01/24- Yudong Gao starts his new lab at Baylor College of Medicine Neuroscience. Watch his lab for big discoveries!
07/24/24- Jaebin Kim publishes his thesis work on a new mechanism of working memory that is presynaptic in origin!
07/22/24- In collaboration with the Pranam Chatterjee lab we use generative AI to design a caged version of TurboID.

Neural development of synapses and their ability to tune their strengths of connections in response to experience are essential for our ability to think, remember, express emotion, etc.  Abnormalities of these synaptic connections contribute to Intellectual Disability, Autism, Alzheimer's Disease, Epilepsy, and Schizophrenia.  We are discovering the inner components of these synapses and the cellular mechanisms underlying these disorders.  Postdoctoral applicants with experience in proteomics, protein engineering, computational biology, 2P-FLIM imaging, or electrophysiology are especially encouraged to apply.